Details of Award
NERC Reference : NER/T/S/2002/00594
Exploitation of deepsea marine isolates - chemical, genomic and transcriptomic characterisation of metabolism in marine streptomycetes.
Grant Award
- Principal Investigator:
- Professor M Goodfellow, Newcastle University, Sch of Biology
- Co-Investigator:
- Professor AC Ward, Newcastle University, Sch of Natural & Environmental Sciences
- Grant held at:
- Newcastle University, Sch of Biology
- Science Area:
- Terrestrial
- Marine
- Overall Classification:
- Marine
- ENRIs:
- Biodiversity
- Science Topics:
- Environmental Microbiology
- Environmental Genomics
- Population Genetics/Evolution
- Environmental biotechnology
- Abstract:
- A diversity of actinomycetes is readily isolated from and detected in deepsea sediments; of these streptomycetes are the most prolific in terms of their secondary metabolic activity. However, marine isolates of streptomycetes, so far, fall in the phylogenetic radiation containing their terrestrial relatives. Accordingly, the relationship of marine and terrestrial actinomycetes has evolutionary, ecological and biotechnological implications. Dereplicated and taxonomically characterised streptomycetes will be: screened by HPLC for novel chemical structures; analysed by comparative genomics using DNA micro-arrays and subtractive hybridisation; and the expression profiles of conserved genes, in response to marine stress (pressure), of marine and terrestrial isolates compared.
- NERC Reference:
- NER/T/S/2002/00594
- Grant Stage:
- Completed
- Scheme:
- Directed Pre FEC
- Grant Status:
- Closed
- Programme:
- Marine & Freshwater Microbial
This grant award has a total value of £113,954
FDAB - Financial Details (Award breakdown by headings)
| Total - Staff | Total - T&S | Total - Other Costs | Total - Indirect Costs |
|---|---|---|---|
| £63,071 | £1,114 | £20,756 | £29,013 |
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