Details of Award
NERC Reference : NER/T/S/2002/00586
Characterisation of biofilm specific, cross-species cell signalling system regulating release of antimicrobial compounds & pigments in marine bacilli
Grant Award
- Principal Investigator:
- Professor G Burgess, Heriot-Watt University, Sch of Life Sciences
- Co-Investigator:
- Professor DR Adams, Heriot-Watt University, Sch of Engineering and Physical Science
- Grant held at:
- Heriot-Watt University, Sch of Life Sciences
- Science Area:
- Marine
- Freshwater
- Overall Classification:
- Marine
- ENRIs:
- Natural Resource Management
- Biodiversity
- Science Topics:
- Environmental Microbiology
- Environmental biotechnology
- Abstract:
- This proposal aims to investigate the identity and role of signal molecules involved in cross-species communication in bacilli. When grown in bioflims, a marine strain of Bacillus licheniformis produces compounds that can elicit the synthesis of antibiotic. This secondary metabolite is only produced when cells are grown at an air-solid interface, and not in submerged bioflims. Planktonically grown cells do not produce antibiotic. However, addition of compounds released from the bioflim grown cells can induce antibiotic production in planktonic cells. Compounds released from bioflims of Bacillus subtilisT and a marine Bacillus pumilus can also induce antibiotic production in B. licheniformis cell suspensions. We will chemically characterise the communication molecules responsible for these effects and investigate the mechanism of their action.
- NERC Reference:
- NER/T/S/2002/00586
- Grant Stage:
- Completed
- Scheme:
- Directed Pre FEC
- Grant Status:
- Closed
- Programme:
- Marine & Freshwater Microbial
This grant award has a total value of £143,019
FDAB - Financial Details (Award breakdown by headings)
| Total - T&S | Total - Staff | Total - Other Costs | Total - Equipment | Total - Indirect Costs |
|---|---|---|---|---|
| £3,480 | £52,090 | £52,991 | £10,496 | £23,961 |
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