Details of Award

NERC Reference : NER/T/S/2002/00572

Identification of the mechanisms of disruption of sexual differentiation in fish exposed to EDCs and their mixtures: a transcriptomic approach.

Principal Investigator:: Professor CR Tyler, University of Liverpool, Sch of Biological Sciences
Co-Investigator:: Professor AR Cossins, University of Liverpool, Institute of Integrative Biology
Grant held at:: University of Liverpool, Sch of Biological Sciences

ENRIs:: Pollution and Waste; Environmental Risks and Hazards
Science Topics:: Water Quality; Pollution; Ecotoxicology; Environmental Genomics

Abstract:: Endocrine disrupting chemicals (EDCs) in STWs effluents cause intersex in wild indigenous fish, which results in reduced reproductive output and potentially has population-level consequences. A major challenge now is to unravel how EDCs impact on the genome of organisms to disrupt sexual development to inform on pathways of action of EDCs and direct the development of systematic screens for these chemicals. We will determine the cascades governing gonad sexual differentiation in the roach (Rutilus rutilus) by characterising the transcriptomic and whole organism responses in fish exposed to known EDCs and their mixtures. Complimentary studies will be undertaken in the zebrafish (ZF, Danio rerio) to assess the applicability of the ZF for informing potential impacts of EDCs on sexual development in wild, indigenous, cyprinid fish.

Authorised funds only

This grant award has a total value of £431,121

Total - Staff	Total - T&S	Total - Other Costs	Total - Equipment	Total - Indirect Costs
£181,528	£7,040	£142,909	£16,140	£83,502

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