Details of Award

NERC Reference : NER/T/S/2002/00195

Large-scale comparative study of microsatellites in microbial genomes: role of repetitive DNA in hypermutability, generation of phenotype & adaption

Principal Investigator:: Dr D Field, NERC CEH (Up to 30.11.2019), NERC CEH - Oxford
Co-Investigator:: Professor R Moxon, University of Oxford, Paediatrics
Grant held at:: NERC CEH (Up to 30.11.2019), NERC CEH - Oxford

ENRIs:: Natural Resource Management; Environmental Risks and Hazards; Biodiversity
Science Topics:: Environmental Genomics; Population Ecology; Population Genetics/Evolution; Environmental Informatics

Abstract:: The wealth of genome sequences currently available provides us with an unprecedented opportunity to study the molecular basis of phenotype and the ecological significance of genetic variation. Despite their mutability, potential utility as molecular markers, and role in phenotypic evolution, microsatellites remain a largely unexplored feature of non-eukaryotic genomes. We propose to conduct a comparative genomic study of the genomes of bacteria, viruses, plasmids, and organelles aimed at identifying factors that control repeat evolution. We will also collect population-level data on repeats in H. influenzae that control the expression of genes known to mediate interactions with the environment. Our work should provide new perspectives on comparative genomic architecture, stability, and the molecular mechanisms underlying phenotypic evolution.

Authorised funds only

This grant award has a total value of £158,352

Total - Staff	Total - T&S	Total - Other Costs	Total - Indirect Costs
£78,685	£3,707	£28,274	£47,689

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