Details of Award
NERC Reference : NER/T/S/2002/00182
Identification of the mechanisms of disruption of sexual differentiation in fish exposed to EDCs and their mixtures: a transcriptomic approach.
Grant Award
- Principal Investigator:
- Professor CR Tyler, University of Exeter, Biosciences
- Co-Investigator:
- Professor AR Cossins, University of Liverpool, Institute of Integrative Biology
- Grant held at:
- University of Exeter, Biosciences
- Science Area:
- Freshwater
- Overall Classification:
- Freshwater
- ENRIs:
- Pollution and Waste
- Environmental Risks and Hazards
- Science Topics:
- Water Quality
- Pollution
- Ecotoxicology
- Environmental Genomics
- Abstract:
- Endocrine disrupting chemicals (EDCs) in STWs effluents cause intersex in wild indigenous fish, which results in reduced reproductive output and potentially has population-level consequences. A major challenge now is to unravel how EDCs impact on the genome of organisms to disrupt sexual development to inform on pathways of action of EDCs and direct the development of systematic screens for these chemicals. We will determine the cascades governing gonad sexual differentiation in the roach (Rutilus rutilus) by characterising the transcriptomic and whole organism responses in fish exposed to known EDCs and their mixtures. Complimentary studies will be undertaken in the zebrafish (ZF, Danio rerio) to assess the applicability of the ZF for informing potential impacts of EDCs on sexual development in wild, indigenous, cyprinid fish.
- Period of Award:
- 3 May 2003 - 2 Nov 2006
- Value:
- £329,474 Lead Split Award
Authorised funds only
- NERC Reference:
- NER/T/S/2002/00182
- Grant Stage:
- Completed
- Scheme:
- Directed Pre FEC
- Grant Status:
- Closed
- Programme:
- Environmental Genomics
This grant award has a total value of £329,474
FDAB - Financial Details (Award breakdown by headings)
| Total - T&S | Total - Staff | Total - Other Costs | Total - Equipment | Total - Indirect Costs |
|---|---|---|---|---|
| £9,626 | £142,831 | £64,742 | £46,575 | £65,703 |
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