Details of Award
NERC Reference : NER/T/S/2001/00299
Environmental fitness of the Burkholderia cepacia complex: feasibility of testing with the genomic approach of signature-tagged transponson mutagenesi
Grant Award
- Principal Investigator:
- Professor E Mahenthiralingam, Cardiff University, School of Biosciences
- Co-Investigator:
- Dr TH Jones, Cardiff University, School of Biosciences
- Co-Investigator:
- Dr A Weightman, Cardiff University, School of Biosciences
- Grant held at:
- Cardiff University, School of Biosciences
- Science Area:
- Terrestrial
- Freshwater
- Overall Classification:
- Terrestrial
- ENRIs:
- Pollution and Waste
- Environmental Risks and Hazards
- Science Topics:
- Environmental Microbiology
- Environmental Genomics
- Environment & Health
- Environmental biotechnology
- Abstract:
- The Burkholderia cepacia complex is a closely related group of free-living bacteria which are ubiquitous in the natural environment. They possess useful bioremediation and biological control properties, but, in contrast, are capable of opportunistic human infection. We will attempt to determine the genetic basis for the environmental fitness of B. cepacia. A modern genetic technology, signature tagged mutagenesis (STM), un-tested in an ecological setting, will be assessed in simple laboratory models of B. cepacia rhizosphere colonization and pollutant degradation. STM is a genomic approach enabling the identification of global gene expression and protein function required for microbial adaptation to diverse habitats. This fundamental research will greatly enhance our understanding of ecological impact and health risks associated with the release of microbial biotechnological agents.
- NERC Reference:
- NER/T/S/2001/00299
- Grant Stage:
- Completed
- Scheme:
- Directed Pre FEC
- Grant Status:
- Closed
- Programme:
- Environmental Genomics
This grant award has a total value of £222,444
FDAB - Financial Details (Award breakdown by headings)
| Total - T&S | Total - Staff | Total - Other Costs | Total - Equipment | Total - Indirect Costs |
|---|---|---|---|---|
| £3,426 | £109,378 | £43,938 | £15,387 | £50,314 |
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