Details of Award

NERC Reference : NER/T/S/2001/00282

Environmental fitness of Burkholderia cepacia complex: feasibility of testing with the genomic approach of signature-tagged transponson mutagenesis

Principal Investigator:: Professor RJ Balment, The University of Manchester, Life Sciences
Co-Investigator:: Dr G Cramb, University of St Andrews, Sch of Medicine
Co-Investigator:: Dr N Hazon, University of St Andrews, Biology
Grant held at:: The University of Manchester, Life Sciences

Abstract:: The ability of some fish to survive in both freshwater and seawater represents one of the most extreme examples of adaptive physiology in the animal kingdom. This project will identify novel genes which are differentially expressed in response to hypo- and hyper-osmotic challenge in teleost fish. This will be achieved by the screening of micro arrays constructed for two native euryhaline species, the eel and flounder. In a second phase the project will examine in detail a selected number of novel differentially expressed genes using molecular, biochemical and physiological techniques to define the function of these systems in relation to osmotic changes in the environment. The results will provide a more complete picture of the mechanisms and pathways involved in the control of osmoregulation in teleost fish to be constructed.

Authorised funds only

This grant award has a total value of £979,422

Total - Staff	Total - T&S	Total - Other Costs	Total - Indirect Costs	Total - Equipment
£398,732	£21,491	£289,544	£205,310	£64,348

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