Details of Award
NERC Reference : NER/M/S/2002/00101
Adaptive sequence variation of the Major Histocompatibility Complex (MHC) in natural populations of the guppy, Poecilia reticulata.
Grant Award
- Principal Investigator:
- Dr C Van Oosterhout, University of Hull, Biological Sciences
- Grant held at:
- University of Hull, Biological Sciences
- Science Area:
- Freshwater
- Overall Classification:
- Freshwater
- ENRIs:
- Biodiversity
- Science Topics:
- Environmental Genomics
- Population Genetics/Evolution
- Population Ecology
- Behavioural Ecology
- Abstract:
- The Major Histocompatibility Complex (MHC) are extremely polymorphic genes with important roles in the vertebrate immune defence. Low MHC-variation may increase disease susceptibility, and MHC can affect mate-choice and sexual selection. The guppy (Poecilia reticulata) will be studied to test the effects of MHC genotype/haplotype on immunocompetence. MHC-genotyped guppies from two natural Trinidadian populations (Upper and Lower Aripo) will be crossed to construct MHC homozygous, heterozygous and 'hybrid' progeny. Infecting these progeny with an ectoparasite (Gyrodactylus turnbulli), and challenging them to a diverse parasite fauna will test their immunological response, parasite-resistance, health, behaviour, reproduction and survival. This work will improve our understanding on the role of selection on maintenance of adaptive genetic variation.
- NERC Reference:
- NER/M/S/2002/00101
- Grant Stage:
- Completed
- Scheme:
- New Investigators Pre FEC
- Grant Status:
- Closed
- Programme:
- New Investigators
This grant award has a total value of £49,897
FDAB - Financial Details (Award breakdown by headings)
| Total - T&S | Total - Staff | Total - Other Costs | Total - Indirect Costs |
|---|---|---|---|
| £535 | £29,001 | £7,020 | £13,340 |
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