Details of Award
NERC Reference : NER/M/S/2001/00075
The maintenance of genetic diversity at the major histocompatibility complex.
Grant Award
- Principal Investigator:
- Professor S Paterson, University of Stirling, Biological and Environmental Sciences
- Grant held at:
- University of Stirling, Biological and Environmental Sciences
- Science Area:
- Terrestrial
- Overall Classification:
- Terrestrial
- ENRIs:
- Environmental Risks and Hazards
- Biodiversity
- Science Topics:
- Population Genetics/Evolution
- Population Ecology
- Community Ecology
- Abstract:
- The major histocompatibility complex (MHC) provides a powerful system to determine the causes and consequences of genetic diversity in host-parasite interactions. Genes within the MHC are central to the host immune response against parasites and show very high levels of polymorphism maintained by balancing selection. However, the mechanism by which this balancing selection occurs is unknown. This proposal will determine this mechanism using a unique rat-nematode system in which the genetic diversity of both the hosts and the parasites can be controlled. The specific objective of this proposal is to test the hypothesis that hosts that are heterozygous at the MHC produce more effective immune responses against a wider range of parasite genotypes and species than hosts that are homozygous at the MHC.
- NERC Reference:
- NER/M/S/2001/00075
- Grant Stage:
- Completed
- Scheme:
- New Investigators Pre FEC
- Grant Status:
- Closed
- Programme:
- New Investigators
This grant award has a total value of £50,659
FDAB - Financial Details (Award breakdown by headings)
| Total - T&S | Total - Staff | Total - Other Costs | Total - Indirect Costs | Total - Equipment |
|---|---|---|---|---|
| £1,421 | £16,968 | £20,588 | £7,806 | £3,878 |
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