Details of Award
NERC Reference : NER/B/S/2002/00285
Generation of thermally differentiated zebrafish strains by selective breeding.
Grant Award
- Principal Investigator:
- Professor AR Cossins, University of Liverpool, Sch of Biological Sciences
- Co-Investigator:
- Dr LU Sneddon, University of Gothenburg, Biological and Environmental Sciences
- Co-Investigator:
- Professor S Kemp, SRUC, Research
- Grant held at:
- University of Liverpool, Sch of Biological Sciences
- Science Area:
- Freshwater
- Overall Classification:
- Freshwater
- ENRIs:
- Natural Resource Management
- Global Change
- Environmental Risks and Hazards
- Biodiversity
- Science Topics:
- Environmental Physiology
- Environmental Genomics
- Population Genetics/Evolution
- Abstract:
- Tolerance of environmental variation is a major issue for all organisms and is one that is subjected to ruthless Darwinian selection. However, with the exception of heat shock proteins, the underlying mechanisms of phenotypic or genotypic tolerance are poorly understood and where mechanisms are proposed the evidence is usually circumstantial. We propose to undertake a genetic quantitative trait analysis to identify loci that contribute to cold tolerance. We propose to use the model vertebrate, the zebrafish, Danio rerio, that offers considerable experimental conveniences and critically whose genomic sequence will shortly be available. This will allow genes in the region of the QTL loci to be explored using more conventional gene and protein profiling techniques. This small project is simply to generate lines of ZF that are divergent in their thermal tolerances. We requests funds to purchase sufficient zebrafish maintenance systems for replicated lines to be produced.
- NERC Reference:
- NER/B/S/2002/00285
- Grant Stage:
- Completed
- Scheme:
- Small Grants Pre FEC
- Grant Status:
- Closed
- Programme:
- Small Grants
This grant award has a total value of £20,870
FDAB - Financial Details (Award breakdown by headings)
| Total - Other Costs | Total - Equipment |
|---|---|
| £2,871 | £18,000 |
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