Details of Award
NERC Reference : NER/A/S/2002/00879
Is the exchange of genes between baculovirus genomes a driving force in the evolution of virulence and host range?
Grant Award
- Principal Investigator:
- Professor RD Possee, NERC CEH (Up to 30.11.2019), NERC CEH - Oxford
- Grant held at:
- NERC CEH (Up to 30.11.2019), NERC CEH - Oxford
- Science Area:
- Terrestrial
- Overall Classification:
- Terrestrial
- ENRIs:
- Natural Resource Management
- Environmental Risks and Hazards
- Biodiversity
- Science Topics:
- Environmental Microbiology
- Environmental Genomics
- Population Genetics/Evolution
- Environmental biotechnology
- Abstract:
- This project will address the evolution of virulence and host range in insect-specific baculoviruses. Genetic exchange between baculoviruses is promoted by many as a mechanism whereby these pathogens may acquire traits beneficial to their ecological fitness. The theory, however, is not supported by significant experimental data, other than by inference from genome sequence analysis. The principal difficulty is the detection of recombinants between baculoviruses that co-infect a common host. This proposal outlines a new strategy whereby genetic exchange between two baculoviruses is achieved artificially. Genes from a baculovirus with a broad host range will be introduced into a baculovirus with a narrow host range. The viability and fitness of the resulting recombinant viruses will be tested to answer the question posed in the title to this project.
- NERC Reference:
- NER/A/S/2002/00879
- Grant Stage:
- Completed
- Scheme:
- Standard Grants Pre FEC
- Grant Status:
- Closed
- Programme:
- Standard Grant
This grant award has a total value of £195,433
FDAB - Financial Details (Award breakdown by headings)
| Total - Staff | Total - T&S | Total - Other Costs | Total - Indirect Costs |
|---|---|---|---|
| £110,965 | £1,136 | £32,290 | £51,045 |
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