Details of Award
NERC Reference : NER/A/S/2001/01217
Gene expression and environmental adaptation: the evolution of hyper-variable multi-gene toxin families from pit viper venoms.
Grant Award
- Principal Investigator:
- Dr A Malhotra, Bangor University, Sch of Biological Sciences
- Co-Investigator:
- Professor R Thorpe, Bangor University, Sch of Biological Sciences
- Co-Investigator:
- Professor J Harris, Newcastle University, Neurology Neurobiology and Psychiatry
- Grant held at:
- Bangor University, Sch of Biological Sciences
- Science Area:
- Terrestrial
- Overall Classification:
- Terrestrial
- ENRIs:
- Biodiversity
- Science Topics:
- Environmental Genomics
- Population Genetics/Evolution
- Systematics & Taxonomy
- Abstract:
- Genome response to an environmental stimuli (i.e., a dietary switch) has been implicated in our preliminary studies of phospholipase A2 (PLA2) isoenzyme variation in Trimeresurus pitvipers. We will survey genetic diversity in the PLA2 and bradykinin potentiating peptide (BPP) multi-gene families in our extensive collection (over 600) of DNA/venom samples from 28+ species. Functional studies will determine the extent of operational homology and patterns of expression will be investigated. 'Hot-spots' of mutation will be identified by reconciling gene trees to species trees and their environmental correlates will be investigated to elucidate generalised mechanisms of evolution in toxin families and to show how allelic variation and gene regulation adapt the organisms to their environment.
- NERC Reference:
- NER/A/S/2001/01217
- Grant Stage:
- Completed
- Scheme:
- Standard Grants Pre FEC
- Grant Status:
- Closed
- Programme:
- Standard Grant
This grant award has a total value of £297,448
FDAB - Financial Details (Award breakdown by headings)
| Total - T&S | Total - Staff | Total - Other Costs | Total - Indirect Costs | Total - Equipment |
|---|---|---|---|---|
| £10,209 | £139,605 | £67,725 | £64,219 | £15,689 |
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