Details of Award
NERC Reference : NER/A/S/2001/01069
Defining the genetic and environmental parameters affecting virus transmission between insect larvae.
Grant Award
- Principal Investigator:
- Professor L King, Oxford Brookes University, Faculty of Health and Life Sciences
- Co-Investigator:
- Professor R. S. Hails, The National Trust, Swindon
- Co-Investigator:
- Professor RD Possee, Oxford Brookes University, Faculty of Health and Life Sciences
- Grant held at:
- Oxford Brookes University, Faculty of Health and Life Sciences
- Science Area:
- Terrestrial
- Overall Classification:
- Terrestrial
- ENRIs:
- Natural Resource Management
- Environmental Risks and Hazards
- Biodiversity
- Science Topics:
- Environmental Microbiology
- Environmental Genomics
- Population Genetics/Evolution
- Environmental biotechnology
- Abstract:
- This project will address the horizontal transmission of baculoviruses between lepidopteran hosts. Recent studies suggest that some baculoviruses encode genes (chitinase, cathepsin and pl0) that produce proteins responsible for liquefying host larvae after death. It is unclear, however, whether this process confers increased fitness on the pathogen in encountering a new host, or is a hindrance by exposing it to solar radiation when it has left the insect. Utilising viruses deficient in one or more of these genes to perform experiments to measure the dynamics of virus transmission to new hosts and exposing virus to simulated sunlight will investigate these questions. We will also determine if there is heritable variation in virus-induced liquefaction of insects by sequential passage of virus through larvae and selection of progeny from hosts tat liquefy early or late.
- NERC Reference:
- NER/A/S/2001/01069
- Grant Stage:
- Completed
- Scheme:
- Standard Grants Pre FEC
- Grant Status:
- Closed
- Programme:
- Standard Grant
This grant award has a total value of £255,801
FDAB - Financial Details (Award breakdown by headings)
| Total - Staff | Total - T&S | Total - Other Costs | Total - Indirect Costs |
|---|---|---|---|
| £131,222 | £1,960 | £51,581 | £71,039 |
If you need further help, please read the user guide.