Details of Award
NERC Reference : NER/A/S/2000/00550
Application of an improved cultured gill epithelium system as a model for branchial effects of waterborne metals.
Grant Award
- Principal Investigator:
- Professor C Hogstrand, King's College London, Life Sciences
- Grant held at:
- King's College London, Life Sciences
- Science Area:
- Freshwater
- Overall Classification:
- Freshwater
- ENRIs:
- Pollution and Waste
- Natural Resource Management
- Environmental Risks and Hazards
- Science Topics:
- Ecotoxicology
- Environmental Physiology
- Abstract:
- Suitable cell culture systems to assess effects of waterborne metals on fish are lacking. A reason for this is that metal speciation dictates toxicity and realistic water chemistry cannot be recreated in cell culture media. We have further developed a fish gilt culture system exists that closely mimics in viva exposure conditions in terms of metal speciation and biological target of toxicity (e.g.. ionocyte. ion transport). The objectives for the proposal are to: 1. Set up the gill epithelium culture at King's College London. 2. Characterise the cultured gill epithelium as a model for metal toxicity. 3. Employ the cultured gill epithelium to measure effects of metal speciation. 4. Use the cultured gill epithelium to separate direct effects of metals from indirect responses: a) Involvement of hormones and cytokines in rnetallothionein expression. b) Regulation of zinc uptake.
- NERC Reference:
- NER/A/S/2000/00550
- Grant Stage:
- Completed
- Scheme:
- Standard Grants Pre FEC
- Grant Status:
- Closed
- Programme:
- Standard Grant
This grant award has a total value of £230,676
FDAB - Financial Details (Award breakdown by headings)
| Total - Staff | Total - T&S | Total - Other Costs | Total - Indirect Costs | Total - Equipment |
|---|---|---|---|---|
| £101,184 | £3,435 | £47,287 | £56,405 | £22,361 |
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