Details of Award
NERC Reference : NE/N007182/1
Air Pollution Impacts on Cardiopulmonary Disease in Beijing: An integrated study of Exposure Science, Toxicogenomics and Environmental Epidemiology
Grant Award
- Principal Investigator:
- Dr M Loh, Institute of Occupational Medicine, Research
- Co-Investigator:
- Mr JF Hurley, Institute of Medicine, UNLISTED
- Co-Investigator:
- Professor P Wilkinson, London Sch of Hygiene & Tropic. Medicine, Public Health and Policy
- Co-Investigator:
- Professor S Reis, UK Centre for Ecology & Hydrology, Atmospheric Chemistry and Effects
- Co-Investigator:
- Professor J Cherrie, Institute of Occupational Medicine, Research
- Grant held at:
- Institute of Occupational Medicine, Research
- Science Area:
- Atmospheric
- Earth
- Freshwater
- Marine
- Terrestrial
- Overall Classification:
- Unknown
- ENRIs:
- Biodiversity
- Environmental Risks and Hazards
- Global Change
- Natural Resource Management
- Pollution and Waste
- Science Topics:
- Aerosols
- Nitrogen oxides
- Tropospheric Processes
- Environment & Health
- Air pollution
- Air quality
- Atmospheric aerosols
- Dose exposure relations
- Oxidative stress
- Particulates
- Urban areas
- Air pollution
- Pollution
- Abstract:
- This proposal aims to do a comprehensive evaluation of air pollution health impacts on cardiopulmonary health through integration of exposure, epidemiology, and toxicology/toxicogenomic studies. We will do detailed assessments of people's exposure to air pollution, estimating exposures for long- and short-term epidemiological analyses, and linking these to epidemiological analyses of long term health impacts based on a cohort study, short-term effects (i.e. biomarkers, blood pressure, heart rhythm, peak flow) based on a panel study, and early life effects based on a birth cohort. Additionally, we test the effect of reducing exposure to fine particles, but not gases, by designing an intervention study where volunteers will wear a face mask and examining the exposure-response relationship for the same short-term effects we evaluate in the panel study. The short-term physiological measurements we conduct in the epidemiological studies will provide insight into the mechanisms by which air pollutions affects cardiopulmonary health. To complement the human based studies into mechanisms of action, our project will also conduct extensive in vivo analyses of mechanistic effects, and early life toxicogenomics/metabonomics. Finally, we will provide practical advice to stakeholders based on our study findings, by assessing the potential value of selected strategies for control of exposure to outdoor health protection in a health risk assessment.
- Period of Award:
- 18 Jan 2016 - 17 Jan 2020
- Value:
- £495,172 Lead Split Award
Authorised funds only
- NERC Reference:
- NE/N007182/1
- Grant Stage:
- Completed
- Scheme:
- Directed - International
- Grant Status:
- Closed
- Programme:
- APHH
This grant award has a total value of £495,172
FDAB - Financial Details (Award breakdown by headings)
| DI - Other Costs | Indirect - Indirect Costs | DA - Investigators | DA - Estate Costs | DI - Staff | DI - T&S | DA - Other Directly Allocated |
|---|---|---|---|---|---|---|
| £68,639 | £146,074 | £38,993 | £43,898 | £161,047 | £36,147 | £374 |
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