Details of Award
NERC Reference : NE/C508085/1
Role of microRNAs in phenotypic plasticity to environmental change.
Grant Award
- Principal Investigator:
- Professor T Dalmay, University College London, Genetics Evolution and Environment
- Co-Investigator:
- Dr J Kinghorn, University of St Andrews, Biology
- Co-Investigator:
- Professor IA Johnston, University of St Andrews, Biology
- Co-Investigator:
- Professor L Partridge, University College London, Genetics Evolution and Environment
- Co-Investigator:
- Professor H Godfray, University of Oxford, Oxford Martin School
- Co-Investigator:
- Professor TA Burke, University of Sheffield, School of Biosciences
- Grant held at:
- University College London, Genetics Evolution and Environment
- Science Area:
- Terrestrial
- Overall Classification:
- Terrestrial
- ENRIs:
- Natural Resource Management
- Global Change
- Biodiversity
- Science Topics:
- Environmental Genomics
- Environmental Physiology
- Population Genetics/Evolution
- Climate & Climate Change
- Abstract:
- One of the challenges of the post-genomic era is to understand how the environment impacts upon the genome. It is likely that much of the phenotypic variation between individuals and species is based on non protein-coding sequences. MicroRNAs (miRNAs) are recently discovered, non-coding, short (18-24 nucleotide) molecules, that direct post-transcriptional regulation of gene expression by binding to miRNAs. This consortium will test the hypothesis that miRNAs play a role in gene expression regulation in response to environmental changes in three species: fruitfly, pufferfish and chicken. miRNAs will be identified in pufferfish and chicken and the sequence of already known miRNAs from Drosophila will be used. The expression profile of miRNAs will be established in response to biotic (parasite infection) and abiotic (temperature) stresses for fruitfly, temperature during early development for pufferfish and egg steroid concentration and condition-dependent plumage pigmentation in birds. miRNAs will be identified that show substantial changes in expression in response to these factors and the phenotypic consequences of manipulating their concentrations determined. Computational and experimental approaches will be used to identify the target genes of these miRNAs.
- Period of Award:
- 1 Oct 2004 - 28 Feb 2009
- Value:
- £332,481 Split Award
Authorised funds only
- NERC Reference:
- NE/C508085/1
- Grant Stage:
- Completed
- Scheme:
- Directed Pre FEC
- Grant Status:
- Closed
- Programme:
- Post Genomics
This grant award has a total value of £332,481
FDAB - Financial Details (Award breakdown by headings)
| Total - Staff | Total - T&S | Total - Other Costs | Total - Indirect Costs |
|---|---|---|---|
| £185,205 | £1,247 | £60,836 | £85,195 |
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